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Intervention Randomly assigned 1:1 to subcutaneous Semaglutide 2.4 mg once-weekly for 52 weeks or placebo Semaglutide treatment was initiated at a dose of 0.25mg once-weekly for the first 4 weeks

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In the RCTs, prebiotics showed similar clinical efficacy to mesalamine, and synbiotics, combined with probiotics and prebiotics, could also significantly decrease the CAI, the levels of intestinal mucosal inflammatory cytokines and fecal calprotectin, but not DAI [308,309,310,311,312]

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